Detalhe da pesquisa
1.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 184(18): 4651-4668.e25, 2021 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34450028
2.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 187(6): 1565-1566, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38490183
3.
Cleaning crew: Soluble TREM2 mops up complement.
Immunity
; 56(8): 1701-1703, 2023 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37557076
4.
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.
EMBO J
; 41(4): e109108, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35019161
5.
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.
Immunity
; 34(6): 854-65, 2011 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21703540
6.
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.
Nature
; 505(7484): 509-14, 2014 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24356306
7.
Corrigendum: Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.
Nature
; 544(7648): 124, 2017 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28329768
8.
STING is a direct innate immune sensor of cyclic di-GMP.
Nature
; 478(7370): 515-8, 2011 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21947006
9.
Mummy, A UDP-N-acetylglucosamine pyrophosphorylase, modulates DPP signaling in the embryonic epidermis of Drosophila.
Dev Biol
; 381(2): 434-45, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23796903
10.
The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.
Infect Immun
; 79(2): 688-94, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21098106
11.
Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila.
PLoS Pathog
; 5(11): e1000665, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19936053
12.
Induction of type I interferons by bacteria.
Cell Microbiol
; 12(7): 881-90, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20482555
13.
Diet-dependent regulation of TGFß impairs reparative innate immune responses after demyelination.
Nat Metab
; 3(2): 211-227, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33619376
14.
Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease.
Neuron
; 108(5): 801-821, 2020 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33096024
15.
Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.
Nat Neurosci
; 23(8): 927-938, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32514138
16.
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
EMBO Mol Med
; 12(4): e11227, 2020 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32154671
17.
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Neuron
; 105(5): 837-854.e9, 2020 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31902528
18.
Author Correction: Diet-dependent regulation of TGFß impairs reparative innate immune responses after demyelination.
Nat Metab
; 5(3): 531, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36823473
19.
Microglia clean up toxic lipids in multiple sclerosis.
Nat Neurosci
; 24(4): 451-452, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33758401
20.
Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells.
Cell Rep
; 12(10): 1555-1563, 2015 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26321639